Dataset Information
Prognostic significance of interleukin-17A-producing colorectal tumour antigen-specific T cells.
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ABSTRACT: Background
The T cell cytokine profile is a key prognostic indicator of post-surgical outcome for colorectal cancer (CRC). Whilst TH1 (IFN-γ+) cell-mediated responses generated in CRC are well documented and are associated with improved survival, antigen-specific TH17 (IL-17A+) responses have not been similarly measured.Methods
We sought to determine the cytokine profile of circulating tumour antigen-(5T4/CEA) specific T cells of 34 CRC patients to address whether antigen-specific IL-17A responses were detectable and whether these were distinct to IFN-γ responses.Results
As with IFN-γ-producing T cells, anti-5T4/CEA TH17 responses were detectable predominantly in early stage (TNM I/II) CRC patients. Moreover, whilst IL-17A was always produced in association with IFN-γ, this release was mainly from two distinct T cell populations rather than by 'dual producing' T cells. Patients mounting both tumour-specific TH1+/TH17+ responses exhibited prolonged relapse-free survival.Conclusions
Tumour antigen-specific TH17 responses play a beneficial role in preventing post-operative colorectal tumour recurrence.
SUBMITTER: Thomson A
PROVIDER: S-EPMC8076199 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Prognostic significance of interleukin-17A-producing colorectal tumour antigen-specific T cells.
British journal of cancer 20210305 9
<h4>Background</h4>The T cell cytokine profile is a key prognostic indicator of post-surgical outcome for colorectal cancer (CRC). Whilst T<sub>H</sub>1 (IFN-γ<sup>+</sup>) cell-mediated responses generated in CRC are well documented and are associated with improved survival, antigen-specific T<sub>H</sub>17 (IL-17A<sup>+</sup>) responses have not been similarly measured.<h4>Methods</h4>We sought to determine the cytokine profile of circulating tumour antigen-(5T4/CEA) specific T cells of 34 CRC ...[more]