A combination of the percentages of IFN-γ⁺CD4⁺T cells and granzyme B⁺CD19⁺B cells is associated with acute hepatic rejection: a case control study.

ABSTRACT:

Background

T cells and B cells play a key role in alloimmune responses. We aimed to characterize the shift of T cell subsets and B cell subsets during acute hepatic rejection, and further determine whether they could serve as a prognostic marker.

Methods

Blood samples together with the clinical data from liver transplant recipients with and without acute hepatic rejection were collected and analyzed as well as from a validation cohort.

Results

Upon activation the expression of TGF-β and granzyme B in CD19⁺B cells, and the expression of IL-2 and IFN-γ in CD4⁺T cells were higher in acute hepatic rejection. However, only the frequencies of granzyme B⁺CD19⁺B cells and IFN-γ⁺CD4⁺T cells correlated with liver

SUBMITTER: Zhu JQ 

PROVIDER: S-EPMC8088570 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature