Slowed Processing Speed Disrupts Patient Expectancy in Late Life Depression.

ABSTRACT:

Objective

Slowed processing speed and executive dysfunction are associated with poor outcomes in Late Life Depression (LLD), though it is unclear why. We investigated whether these variables interfere with the development of positive treatment expectancies in an antidepressant trial.

Methods

Depressed older subjects were randomized to Open (intended to increase patient expectancy) or Placebo-controlled (termed 'Hidden,' intended to decrease expectancy) administration of antidepressant medication for 8 weeks. Analysis of covariance analyzed the between-group difference on expectancy (Credibility and Expectancy Scale [CES]) and depression (Hamilton Rating Scale for Depression [HRSD], Clinical Global Impressions [CGI] Severity). Moderator analyses examined whether these Open ve

SUBMITTER: Rutherford BR 

PROVIDER: S-EPMC8099936 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature