UTX promotes CD8⁺ T cell-mediated antiviral defenses but reduces T cell durability.

ABSTRACT: Persistent virus infections can cause pathogenesis that is debilitating or lethal. During these infections, virus-specific T cells fail to protect due to weakened antiviral activity or failure to persist. These outcomes are governed by histone modifications, although it is unknown which enzymes contribute to T cell loss or impaired function over time. In this study, we show that T cell receptor-stimulated CD8⁺ T cells increase their expression of UTX (ubiquitously transcribed tetratricopeptide repeat, X chromosome) to enhance gene expression. During chronic lymphocytic choriomeningitis virus (LCMV) infection in mice, UTX binds to enhancers and transcription start sites of effector genes, allowing for improved cytotoxic T lymphocyte (CTL)-mediated protection, independent of its t

SUBMITTER: Mitchell JE 

PROVIDER: S-EPMC8112613 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature