Lipid and lipoprotein predictors of functional outcomes and long-term mortality after surgical sepsis.

ABSTRACT:

Rationale

Sepsis is a life-threatening, dysregulated response to infection. Lipid biomarkers including cholesterol are dynamically regulated during sepsis and predict short-term outcomes. In this study, we investigated the predictive ability of lipid biomarkers for physical function and long-term mortality after sepsis.

Methods

Prospective cohort study of sepsis patients admitted to a surgical intensive-care unit (ICU) within 24 h of sepsis bundle initiation. Samples were obtained at enrollment for lipid biomarkers. Multivariate regression models determined independent risk factors predictive of poor performance status (Zubrod score of 3/4/5) or survival at 1-year follow-up.

Measurements and main results

The study included 104 patients with surgical sepsis. Enrollment

SUBMITTER: Guirgis FW 

PROVIDER: S-EPMC8136376 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature