Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology.
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ABSTRACT:
SUBMITTER: Okombo J
PROVIDER: S-EPMC8162148 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology.
Okombo John J Kanai Mariko M Deni Ioanna I Fidock David A DA
Trends in parasitology 20210311 6
Recent progress in genomics and molecular genetics has empowered novel approaches to study gene functions in disease-causing pathogens. In the human malaria parasite Plasmodium falciparum, the application of genome-based analyses, site-directed genome editing, and genetic systems that allow for temporal and quantitative regulation of gene and protein expression have been invaluable in defining the genetic basis of antimalarial resistance and elucidating candidate targets to accelerate drug disco ...[more]
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