Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits.

ABSTRACT:

Background

The origin of sex differences in prevalence and presentation of neuropsychiatric and behavioral traits is largely unknown. Given established genetic contributions and correlations, we tested for a sex-differentiated genetic architecture within and between traits.

Methods

Using European ancestry genome-wide association summary statistics for 20 neuropsychiatric and behavioral traits, we tested for sex differences in single nucleotide polymorphism (SNP)-based heritability and genetic correlation (r_g < 1). For each trait, we computed per-SNP z scores from sex-stratified regression coefficients and identified genes with sex-differentiated effects using a gene-based approach. We calculated correlation coefficients between z scores to test for shared sex-diff

SUBMITTER: Martin J 

PROVIDER: S-EPMC8163257 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature