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Selective α,δ-hydrocarboxylation of conjugated dienes utilizing CO₂ and electrosynthesis.

ABSTRACT: To date the majority of diene carboxylation processes afford the α,δ-dicarboxylated product, the selective mono-carboxylation of dienes is a significant challenge and the major product reported under transition metal catalysis arises from carboxylation at the α-carbon. Herein we report a new electrosynthetic approach, that does not rely on a sacrificial electrode, the reported method allows unprecedented direct access to carboxylic acids derived from dienes at the δ-position. In addition, the α,δ-dicarboxylic acid or the α,δ-reduced alkene can be easily accessed by simple modification of the reaction conditions.

SUBMITTER: Sheta AM

PROVIDER: S-EPMC8163448 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Selective α,δ-hydrocarboxylation of conjugated dienes utilizing CO2 and electrosynthesis.

Sheta Ahmed M AM Mashaly Mohammad A MA Said Samy B SB Elmorsy Saad S SS Malkov Andrei V AV Buckley Benjamin R BR

Chemical science 20200720 34

To date the majority of diene carboxylation processes afford the α,δ-dicarboxylated product, the selective mono-carboxylation of dienes is a significant challenge and the major product reported under transition metal catalysis arises from carboxylation at the α-carbon. Herein we report a new electrosynthetic approach, that does not rely on a sacrificial electrode, the reported method allows unprecedented direct access to carboxylic acids derived from dienes at the δ-position. In addition, the α, ...[more]

PMID: 34123160

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