Relationship between amyloid and tau levels and its impact on tau spreading.

ABSTRACT:

Purpose

Previous studies have shown that Aβ-amyloid (Aβ) likely promotes tau to spread beyond the medial temporal lobe. However, the Aβ levels necessary for tau to spread in the neocortex is still unclear.

Methods

Four hundred sixty-six participants underwent tau imaging with [18F]MK6420 and Aβ imaging with [¹⁸F]NAV4694. Aβ scans were quantified on the Centiloid (CL) scale with a cut-off of 25 CL for abnormal levels of Aβ (A+). Tau scans were quantified in three regions of interest (ROI) (mesial temporal (Me); temporoparietal neocortex (Te); and rest of neocortex (R)) and four mesial temporal region (entorhinal cortex, amygdala, hippocampus, and parahippocampus). Regional tau thresholds were established as the 95%ile of the cognitively unimpaired A- subjects. The

SUBMITTER: Dore V 

PROVIDER: S-EPMC8175299 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature