High CPAP vs. NIPPV in preterm neonates - A physiological cross-over study.

ABSTRACT:

Objective

To evaluate the physiological impact of high CPAP (≥9 cmH₂O) vs. NIPPV at equivalent mean airway pressures.

Study design

In this cross-over study, preterm neonates on high CPAP or NIPPV were placed on the alternate mode. After 30 min, left and right ventricular cardiac output and work of breathing indices were assessed, following which patients were placed back on the original mode and a similar procedure ensued.

Results

Fifteen infants with mean (SD) postmenstrual age 32.7 (3.0) weeks, and weight 1569 (564) grams were included. No differences in LVO [320 (63) vs. 331 (86) mL/kg/min, P = 0.46] or RVO [420 (135) vs. 437 (141) mL/kg/min, P = 0.19] were noted during high CPAP vs. NIPPV, along with no differences in work of breathing indices.

Concl

SUBMITTER: Mukerji A 

PROVIDER: S-EPMC8179075 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature