Inflammation, negative affect, and amyloid burden in Alzheimer's disease: Insights from the kynurenine pathway.

ABSTRACT:

Background

Depressive symptoms in Alzheimer's disease (AD) predict worse cognitive and functional outcomes. Both AD and major depression inflammatory processes are characterized by shunted tryptophan metabolism away from serotonin (5-HT) and toward the neuroinflammatory kynurenine (Kyn) pathway. The present study assessed associations between Kyn and behavioral, neuroanatomical, neuropathological, and physiological outcomes common to both AD and negative affect across the AD continuum.

Methods

In 58 cognitively normal, 396 mild cognitive impairment, and 112 AD participants from the Alzheimer's Disease Neuroimaging Initiative-1 (ADNI1) cohort, serum markers of 5-HT, tryptophan, and Kyn were measured and their relationships investigated with immunologic markers, affect and fun

SUBMITTER: Willette AA 

PROVIDER: S-EPMC8187283 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature