Maternal iron deficiency perturbs embryonic cardiovascular development in mice.
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ABSTRACT:
SUBMITTER: Kalisch-Smith JI
PROVIDER: S-EPMC8187484 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
Maternal iron deficiency perturbs embryonic cardiovascular development in mice.
Kalisch-Smith Jacinta I JI Ved Nikita N Szumska Dorota D Munro Jacob J Troup Michael M Harris Shelley E SE Rodriguez-Caro Helena H Jacquemot Aimée A Miller Jack J JJ Stuart Eleanor M EM Wolna Magda M Hardman Emily E Prin Fabrice F Lana-Elola Eva E Aoidi Rifdat R Fisher Elizabeth M C EMC Tybulewicz Victor L J VLJ Mohun Timothy J TJ Lakhal-Littleton Samira S De Val Sarah S Giannoulatou Eleni E Sparrow Duncan B DB
Nature communications 20210608 1
Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular defects in the offspring. These defects likely arise from increased retinoic acid sig ...[more]
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