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Aging-Related Metabolic Dysfunction in the Salivary Gland: A Review of the Literature.

ABSTRACT: Aging-related salivary dysfunction commonly induces the poor oral health, including decreased saliva flow and dental caries. Although the clinical significance of the salivary glands is well-known, the complex metabolic pathways contributing to the aging-dysfunction process are only beginning to be uncovered. Here, we provide a comprehensive overview of the metabolic changes in aging-mediated salivary gland dysfunction as a key aspect of oral physiology. Several metabolic neuropeptides or hormones are involved in causing or contributing to salivary gland dysfunction, including hyposalivation and age-related diseases. Thus, aging-related metabolism holds promise for early diagnosis, increased choice of therapy and the identification of new metabolic pathways that could potentially be targeted in salivary gland dysfunction.

SUBMITTER: Toan NK

PROVIDER: S-EPMC8198609 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Aging-Related Metabolic Dysfunction in the Salivary Gland: A Review of the Literature.

Toan Nguyen Khanh NK Ahn Sang-Gun SG

International journal of molecular sciences 20210529 11

Aging-related salivary dysfunction commonly induces the poor oral health, including decreased saliva flow and dental caries. Although the clinical significance of the salivary glands is well-known, the complex metabolic pathways contributing to the aging-dysfunction process are only beginning to be uncovered. Here, we provide a comprehensive overview of the metabolic changes in aging-mediated salivary gland dysfunction as a key aspect of oral physiology. Several metabolic neuropeptides or hormon ...[more]

PMID: 34072470

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