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Ni-catalyzed hydroaminoalkylation of alkynes with amines.

ABSTRACT: Allylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but their synthesis via hydroaminoalkylation of alkynes with amines has been a formidable challenge. Here, we report a late transition metal Ni-catalyzed hydroaminoalkylation of alkynes with N-sulfonyl amines, providing a series of allylic amines in up to 94% yield. Double ligands of N-heterocyclic carbene (IPr) and tricyclohexylphosphine (PCy₃) effectively promote the reaction.

SUBMITTER: Yao WW

PROVIDER: S-EPMC8217523 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Ni-catalyzed hydroaminoalkylation of alkynes with amines.

Yao Wei-Wei WW Li Ran R Chen Hao H Chen Ming-Kai MK Luan Yu-Xin YX Wang Yi Y Yu Zhi-Xiang ZX Ye Mengchun M

Nature communications 20210621 1

Allylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but their synthesis via hydroaminoalkylation of alkynes with amines has been a formidable challenge. Here, we report a late transition metal Ni-catalyzed hydroaminoalkylation of alkynes with N-sulfonyl amines, providing a series of allylic amines in up to 94% yield. Double ligands of N-heterocyclic carbene (IPr) and tricyclohexylphosphine (PCy<sub>3</sub>) effectively promote the reaction. ...[more]

PMID: 34155203

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