A Novel Ferroptosis-Related Gene Signature for Overall Survival Prediction in Patients With Breast Cancer.

ABSTRACT:

Introduction

Breast cancer is the most common malignant tumor in women worldwide. However, advanced multidisciplinary therapy cannot rescue the mortality of high-risk breast cancer metastasis. Ferroptosis is a newly discovered form of regulating cell death that related to cancer treatment, especially in eradicating aggressive malignancies that are resistant to traditional therapies. However, the prognostic value of ferroptosis-related gene in breast cancer remains unknown.

Materials and methods

In this study, a total of 1,057 breast cancer RNA expression data with clinical and follow-up information were downloaded from the TCGA cohort, multivariate Cox regression was used to construct the 11-gene prognostic ferroptosis-related gene signature. The breast cancer patients from

SUBMITTER: Zhu L 

PROVIDER: S-EPMC8247647 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature