Profiling the Biochemical Signature of GBA-Related Parkinson's Disease in Peripheral Blood Mononuclear Cells.

ABSTRACT:

Background

GBA mutations are the commonest genetic risk factor for Parkinson's disease (PD) and also impact disease progression.

Objective

The objective of this study was to define a biochemical profile that could distinguish GBA-PD from non-mutated PD.

Methods

29 GBA-PD, 37 non-mutated PD, and 40 controls were recruited; α-synuclein levels in plasma, exosomes, and peripheral blood mononuclear cells were analyzed, GCase and main GCase-related lysosomal proteins in peripheral blood mononuclear cells were measured.

Results

Assessment of plasma and exosomal α-synuclein levels did not allow differentiation between GBA-PD and non-mutated PD; conversely, measurements in peripheral blood mononuclear cells clearly distinguished GBA-PD from non-mutated PD, with the form

SUBMITTER: Avenali M 

PROVIDER: S-EPMC8247888 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature