Dataset Information

Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients.

ABSTRACT:

Introduction

Dementia has been associated with COVID-19 prevalence, but whether this reflects higher infection, older age of patients, or disease severity remains unclear.

Methods

We investigated a cohort of 12,863 UK Biobank community-dwelling individuals > 65 years old (1814 individuals ≥ 80 years old) tested for COVID-19. Individuals were stratified by age to account for age as a confounder. Risk factors were analyzed for COVID-19-positive diagnosis, hospitalization, and death.

Results

All-cause dementia, Alzheimer's disease (AD), and Parkinson's disease (PD) were associated with COVID-19-positive diagnosis, and all-cause dementia and AD remained associated in individuals ≥ 80 years old. All-cause dementia, AD, or PD were not risk factors for overall hospitalization, but increased the risk of hospitalization of COVID-19 patients. All-cause dementia and AD increased the risk of COVID-19-related death, and all-cause dementia was uniquely associated with increased death in ≥ 80-year-old patients.

Discussion

All-cause dementia and AD are age-independent risk factors for disease severity and death in COVID-19.

SUBMITTER: Tahira AC

PROVIDER: S-EPMC8250282 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Publications

Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients.

Tahira Ana C AC Verjovski-Almeida Sergio S Ferreira Sergio T ST

Alzheimer's & dementia : the journal of the Alzheimer's Association 20210421 11

<h4>Introduction</h4>Dementia has been associated with COVID-19 prevalence, but whether this reflects higher infection, older age of patients, or disease severity remains unclear.<h4>Methods</h4>We investigated a cohort of 12,863 UK Biobank community-dwelling individuals > 65 years old (1814 individuals ≥ 80 years old) tested for COVID-19. Individuals were stratified by age to account for age as a confounder. Risk factors were analyzed for COVID-19-positive diagnosis, hospitalization, and death. ...[more]

PMID: 33881211

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Dataset Information

Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients.

Introduction

Methods

Results

Discussion

Publications

Dementia is an age-independent risk factor for severity and death in COVID-19 inpatients.

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