MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It.
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ABSTRACT:
SUBMITTER: Shklovskaya E
PROVIDER: S-EPMC8268865 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Publications
MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It.
Shklovskaya Elena E Rizos Helen H
International journal of molecular sciences 20210623 13
It is now well accepted that the immune system can control cancer growth. However, tumors escape immune-mediated control through multiple mechanisms and the downregulation or loss of major histocompatibility class (MHC)-I molecules is a common immune escape mechanism in many cancers. MHC-I molecules present antigenic peptides to cytotoxic T cells, and MHC-I loss can render tumor cells invisible to the immune system. In this review, we examine the dysregulation of MHC-I expression in cancer, expl ...[more]
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