State-dependent responses to intracranial brain stimulation in a patient with depression.
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ABSTRACT:
SUBMITTER: Scangos KW
PROVIDER: S-EPMC8284979 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
State-dependent responses to intracranial brain stimulation in a patient with depression.
Scangos Katherine W KW Makhoul Ghassan S GS Sugrue Leo P LP Chang Edward F EF Krystal Andrew D AD
Nature medicine 20210118 2
Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in onset, reproducible, and context and state dependent. Results provide proof of concept ...[more]
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