Stability of MRI contrast agents in high-energy radiation of a 1.5T MR-Linac.

ABSTRACT:

Background

Gadolinium-based contrast is often used when acquiring MR images for radiation therapy planning for better target delineation. In some situations, patients may still have residual MRI contrast agents in their tissue while being treated with high-energy radiation. This is especially true when MRI contrast agents are administered during adaptive treatment replanning for patients treated on MR-Linac systems.

Purpose

The purpose of this study was to analyze the molecular stability of MRI contrast agents when exposed to high energy photons and the associated secondary electrons in a 1.5T MR-Linac system. This was the first step in assessing the safety of administering MRI contrast agents throughout the course of treatment.

Materials and methods

Two common MRI co

SUBMITTER: Wang J 

PROVIDER: S-EPMC8324543 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature