Innate immunity - the hallmark of Helicobacter pylori infection in pediatric chronic gastritis.

ABSTRACT:

Background

Innate immunity was found to be associated with both persistence of Helicobacter pylori (H. pylori) infection and increased risk of gastric cancer.

Aim

To identify the risk factors associated with H. pylori infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in children.

Methods

We performed a study of 155 children with digestive symptoms, who were divided into two groups according to the histopathological exam: Group 1 - 48 children with H. pylori-induced chronic gastritis, and Group 2 - control group.

Results

Rural area and poor living conditions were significantly associated with H. pylori chronic gastritis (P = 0.0042/P < 0.0001). Both po

SUBMITTER: Melit LE 

PROVIDER: S-EPMC8362532 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature