IGF2BP2-modified circular RNA circARHGAP12 promotes cervical cancer progression by interacting m⁶A/FOXM1 manner.

ABSTRACT: Emerging evidence indicates that circular RNA (circRNA) and N⁶-methyladenosine (m⁶A) play critical roles in cervical cancer. However, the synergistic effect of circRNA and m⁶A on cervical cancer progression is unclear. In the present study, our sequencing data revealed that a novel m⁶A-modified circRNA (circARHGAP12, hsa_circ_0000231) upregulated in the cervical cancer tissue and cells. Interestingly, the m⁶A modification of circARHGAP12 could amplify its enrichment. Functional experiments illustrated that circARHGAP12 promoted the tumor progression of cervical cancer in vivo and vitro. Furthermore, MeRIP-Seq illustrated that there was a remarkable m⁶A site in FOXM1 mRNA. CircARHGAP12 interacted with m⁶A reader IG

SUBMITTER: Ji F 

PROVIDER: S-EPMC8364552 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature