Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease.

ABSTRACT: Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer's disease, but the functional brain mechanisms that support cognitive resilience remain elusive. Given previous findings in normal ageing, we tested the hypothesis that higher segregation of the brain's connectome into distinct functional networks represents a functional mechanism underlying cognitive resilience in Alzheimer's disease. Using resting-state functional MRI, we assessed both resting-state functional MRI global system segregation, i.e. the balance of between-network to within-network connectivity, and the alternate index of modularity Q as predictors of cognitive resilience. We performed all analyses in two independent samples for validation: (i) 108 individuals with autosomal dominantly in

SUBMITTER: Ewers M 

PROVIDER: S-EPMC8370409 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature