Diagnostic accuracy of the Cogstate Brief Battery for prevalent MCI and prodromal AD (MCI A⁺ T⁺ ) in a population-based sample.

ABSTRACT:

Introduction

This study evaluated the diagnostic accuracy of the Cogstate Brief Battery (CBB) for mild cognitive impairment (MCI) and prodromal Alzheimer's disease (AD) in a population-based sample.

Methods

Participants included adults ages 50+ classified as cognitively unimpaired (CU, n = 2866) or MCI (n = 226), and a subset with amyloid (A) and tau (T) positron emission tomography who were AD biomarker negative (A-T-) or had prodromal AD (A+T+).

Results

Diagnostic accuracy of the Learning/Working Memory Composite (Lrn/WM) for discriminating all CU and MCI was moderate (area under the curve [AUC] = 0.75), but improved when discriminating CU A-T- and MCI A+T+ (AUC = 0.93) and when differentiating MCI participants without AD biomarkers from those with prodromal AD (AUC

SUBMITTER: Alden EC 

PROVIDER: S-EPMC8371696 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature