Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC8375188 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Liu Siyao S Thennavan Aatish A Garay Joseph P JP Marron J S JS Perou Charles M CM
Genome biology 20210819 1
Single-cell RNA sequencing (scRNA-seq) provides new opportunities to characterize cell populations, typically accomplished through some type of clustering analysis. Estimation of the optimal cluster number (K) is a crucial step but often ignored. Our approach improves most current scRNA-seq cluster methods by providing an objective estimation of the number of groups using a multi-resolution perspective. MultiK is a tool for objective selection of insightful Ks and achieves high robustness throug ...[more]