The role of NKX2-5 gene polymorphisms in congenital heart disease (CHD): a systematic review and meta-analysis.

ABSTRACT:

Background

The gene NKX2-5 is a key transcription factor that plays an essential role in normal cardiac development. Although some recent studies have studied the role of polymorphisms in the NKX2-5 gene in congenital heart diseases (CHDs), the results were not consistent and remained uncertain. Therefore, we conduct a review of literature and investigate the association of genetic polymorphisms with CHDs.

Results

We selected seventeen studies regarding the association of NKX2-5 gene rs2277923 polymorphism with CHDs. Overall, in all the tested genetic models, the 63A > G polymorphism was not significantly associated with increased congenital heart defects risk. We used pooled odds ratios (OR) to calculate the association of CHDs with rs2277923 including allelic model: OR 1.0

SUBMITTER: Ashiq S 

PROVIDER: S-EPMC8380205 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature