The relationship between the effect-site concentration of propofol and sedation scale in children: a pharmacodynamic modeling study.

ABSTRACT:

Background

Continuous infusion of propofol has been used to achieve sedation in children. However, the relationship between the effect-site concentration (C_e) of propofol and sedation scale has not been previously examined. The objective of this study was to investigate the relationship between the C_e of propofol and the University of Michigan Sedation Scale (UMSS) score in children with population pharmacodynamic modeling.

Methods

A total of 30 patients (aged 3 to 6 years) who underwent surgery under general anesthesia with propofol and remifentanil lasting more than 1 h were enrolled in this study. Sedation levels were evaluated using the UMSS score every 20 s by a 1 μg/mL stepwise increase in the C_e of propofol during the induction of anes

SUBMITTER: Jang YE 

PROVIDER: S-EPMC8427954 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature