Vaccination induces rapid protection against bacterial pneumonia via training alveolar macrophage in mice.

ABSTRACT: Vaccination strategies for rapid protection against multidrug-resistant bacterial infection are very important, especially for hospitalized patients who have high risk of exposure to these bacteria. However, few such vaccination strategies exist due to a shortage of knowledge supporting their rapid effect. Here, we demonstrated that a single intranasal immunization of inactivated whole cell of Acinetobacter baumannii elicits rapid protection against broad A. baumannii-infected pneumonia via training of innate immune response in Rag1^-/- mice. Immunization-trained alveolar macrophages (AMs) showed enhanced TNF-α production upon restimulation. Adoptive transfer of immunization-trained AMs into naive mice mediated rapid protection against infection. Elevated TLR

SUBMITTER: Gu H 

PROVIDER: S-EPMC8455131 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature