Antimalarials may reduce cancer risk in patients with systemic lupus erythematosus: a systematic review and meta-analysis of prospective studies.

ABSTRACT:

Objective

To investigate the effect of antimalarials on cancer risk in patients with systemic lupus erythematosus (SLE).

Methods

PubMed, EMBASE, Web of Science, and the Cochrane Library were searched from their inception to October 3, 2020. Relative risk (RR) with 95% confidence intervals (CI) was used to evaluate the results. Subgroup analyses were used to assess heterogeneity. A funnel plot was used to explore publication bias. STATA was applied for all analyses.

Results

A total of nine studies consisted of four nested case-control, two case-cohort and three cohort studies were included. The results showed that antimalarials might reduce the risk of cancer in SLE (RR = 0.68, 95%CI: 0.55-0.85). In the subgroup analysis of four nested case-control and two case-cohort

SUBMITTER: Li XB 

PROVIDER: S-EPMC8462850 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature