Dataset Information

Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort.

ABSTRACT:

Objectives

Vitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance.

Methods

The Systemic Lupus International Collaborating Clinics (SLICC) enrolled patients recently diagnosed with SLE (<15 months) from 33 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected. Vitamin D level was defined according to tertiles based on distribution across this cohort, which were set at T1 (10-36 nmol/l), T2 (37-60 nmol/l) and T3 (61-174 nmol/l). MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Insulin resistance was determined using the HOMA-IR model. Linear and logistic regressions were used to assess the association of variables with vitamin D levels.

Results

Of the 1847 patients, 1163 (63%) had vitamin D measured and 398 (34.2%) subjects were in the lowest 25(OH)D tertile. MetS was present in 286 of 860 (33%) patients whose status could be determined. Patients with lower 25(OH)D were more likely to have MetS and higher HOMA-IR. The MetS components, hypertension, hypertriglyceridemia and decreased high-density lipoprotein (HDL) were all significantly associated with lower 25(OH)D. Increased average glucocorticoid exposure was associated with higher insulin resistance.

Conclusions

MetS and insulin resistance are associated with lower vitamin D in patients with SLE. Further studies could determine whether vitamin D repletion confers better control of these cardiovascular risk factors and improve long-term outcomes in SLE.

SUBMITTER: Chew C

PROVIDER: S-EPMC8487307 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort.

Chew Christine C Reynolds John A JA Lertratanakul Apinya A Wu Peggy P Urowitz Murray M Gladman Dafna D DD Fortin Paul R PR Bae Sang-Cheol SC Gordon Caroline C Clarke Ann E AE Bernatsky Sasha S Hanly John G JG Isenberg David D Rahman Anisur A Sanchez-Guerrero Jorge J Romero-Diaz Juanita J Merrill Joan J Wallace Daniel D Ginzler Ellen E Khamashta Munther M Nived Ola O Jönsen Andreas A Steinsson Kristjan K Manzi Susan S Kalunian Ken K Dooley Mary Anne MA Petri Michelle M Aranow Cynthia C van Vollenhoven Ronald R Stoll Thomas T Alarcón Graciela S GS Lim S Sam SS Ruiz-Irastorza Guillermo G Peschken Christine A CA Askanase Anca D AD Kamen Diane L DL İnanç Murat M Ramsey-Goldman Rosalind R Bruce Ian N IN

Rheumatology (Oxford, England) 20211001 10

<h4>Objectives</h4>Vitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance.<h4>Methods</h4>The Systemic Lupus International Collaborating Clinics (SLICC) enrolled patients recently diagnosed with SLE (<15 months) from 33 centres across 11 countries from 2000. Clinical, laboratory and therapeutic ...[more]

PMID: 33555325

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Dataset Information

Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort.

Objectives

Methods

Results

Conclusions

Publications

Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort.

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