SLC-30A9 is required for Zn²⁺ homeostasis, Zn²⁺ mobilization, and mitochondrial health.

ABSTRACT: The trace element zinc is essential for many aspects of physiology. The mitochondrion is a major Zn²⁺ store, and excessive mitochondrial Zn²⁺ is linked to neurodegeneration. How mitochondria maintain their Zn²⁺ homeostasis is unknown. Here, we find that the SLC-30A9 transporter localizes on mitochondria and is required for export of Zn²⁺ from mitochondria in both Caenorhabditis elegans and human cells. Loss of slc-30a9 leads to elevated Zn²⁺ levels in mitochondria, a severely swollen mitochondrial matrix in many tissues, compromised mitochondrial metabolic function, reductive stress, and induction of the mitochondrial stress response. SLC-30A9 is also essential for organismal fertility and sperm activation in C. elegan

SUBMITTER: Deng H 

PROVIDER: S-EPMC8536367 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature