Tristetraprolin Prevents Gastric Metaplasia in Mice by Suppressing Pathogenic Inflammation.

ABSTRACT:

Background & aims

Aberrant immune activation is associated with numerous inflammatory and autoimmune diseases and contributes to cancer development and progression. Within the stomach, inflammation drives a well-established sequence from gastritis to metaplasia, eventually resulting in adenocarcinoma. Unfortunately, the processes that regulate gastric inflammation and prevent carcinogenesis remain unknown. Tristetraprolin (TTP) is an RNA-binding protein that promotes the turnover of numerous proinflammatory and oncogenic messenger RNAs. Here, we assess the role of TTP in regulating gastric inflammation and spasmolytic polypeptide-expressing metaplasia (SPEM) development.

Methods

We used a TTP-overexpressing model, the TTPΔadenylate-uridylate rich element mouse, to examine wh

SUBMITTER: Busada JT 

PROVIDER: S-EPMC8554534 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature