HDL proteome remodeling associates with COVID-19 severity.

ABSTRACT:

Background

Besides the well-accepted role in lipid metabolism, high-density lipoprotein (HDL) also seems to participate in host immune response against infectious diseases.

Objective

We used a quantitative proteomic approach to test the hypothesis that alterations in HDL proteome associate with severity of Coronavirus disease 2019 (COVID-19).

Methods

Based on clinical criteria, subjects (n=41) diagnosed with COVID-19 were divided into two groups: a group of subjects presenting mild symptoms and a second group displaying severe symptoms and requiring hospitalization. Using a proteomic approach, we quantified the levels of 29 proteins in HDL particles derived from these subjects.

Results

We showed that the levels of serum amyloid A 1 and 2 (SAA1 and SAA2, respect

SUBMITTER: Souza Junior DR 

PROVIDER: S-EPMC8557113 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature