Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis.

ABSTRACT:

Background

Urinary uromodulin (uUMOD) is one of the novel biomarkers for predicting AKI. However, currently available publications showed inconsistent results. We designed this meta-analysis to evaluate the potential association between uUMOD and AKI.

Methods

We searched research articles with no language restriction in Medline, Web of Science, Cochrane Library, Embase, and 3 Chinese datasets from inception to February 2021. We used random-effects models to estimate the standardized mean difference (SMD) between patients with AKI or not, while the leave-one-out method and random-effects meta-regression to evaluate the sensitivity and the impact of potential confounders such as age and surgery.

Results

The meta-analysis comprising 3148 subjects from 11 studies showed t

SUBMITTER: You R 

PROVIDER: S-EPMC8591828 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature