Dataset Information

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis.

ABSTRACT:

Background

Urinary uromodulin (uUMOD) is one of the novel biomarkers for predicting AKI. However, currently available publications showed inconsistent results. We designed this meta-analysis to evaluate the potential association between uUMOD and AKI.

Methods

We searched research articles with no language restriction in Medline, Web of Science, Cochrane Library, Embase, and 3 Chinese datasets from inception to February 2021. We used random-effects models to estimate the standardized mean difference (SMD) between patients with AKI or not, while the leave-one-out method and random-effects meta-regression to evaluate the sensitivity and the impact of potential confounders such as age and surgery.

Results

The meta-analysis comprising 3148 subjects from 11 studies showed that the uUMOD of the AKI group is significantly lower than the non-AKI group (SMD: - 0.71; 95% confidence interval (CI), - 1.00, - 0.42, P < 0. 001, I² = 78.8%). Subgroup analysis revealed the difference is also significant in a different age, surgery condition, and assay time but not acute rejection (AR) group, especially in children (SMD: - 1.21, 95% CI: - 1.80, - 0.61; P < 0.001) and patients undergoing surgery (SMD: - 1.03, 95% CI: - 1.75, - 0.30; P < 0.001). Lower uromodulin is associated with higher odds for AKI incidence (odds ratio = 2.47, 95% CI: 1.12, 5.47; P < 0.001, I² = 89%). Meta-reggression found that age was associated with the SMD of uUMOD. The study outcome was reliably confirmed by the sensitivity analysis.

Conclusion

The present study suggested a negative association between uUMOD and AKI especially in children and surgical patients.

SUBMITTER: You R

PROVIDER: S-EPMC8591828 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Publications

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis.

You Ruilian R Zheng Hua H Xu Lubin L Ma Tiantian T Chen Gang G Xia Peng P Fan Xiaohong X Ji Peili P Wang Li L Chen Limeng L

Journal of intensive care 20211115 1

<h4>Background</h4>Urinary uromodulin (uUMOD) is one of the novel biomarkers for predicting AKI. However, currently available publications showed inconsistent results. We designed this meta-analysis to evaluate the potential association between uUMOD and AKI.<h4>Methods</h4>We searched research articles with no language restriction in Medline, Web of Science, Cochrane Library, Embase, and 3 Chinese datasets from inception to February 2021. We used random-effects models to estimate the standardiz ...[more]

PMID: 34782019

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Dataset Information

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis.

Background

Methods

Results

Conclusion

Publications

Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis.

Similar Datasets

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