Ontology highlight
ABSTRACT:
SUBMITTER: Oda Y
PROVIDER: S-EPMC8597994 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Oda Yukako Y Takahashi Chisato C Harada Shota S Nakamura Shun S Sun Daxiao D Kiso Kazumi K Urata Yuko Y Miyachi Hitoshi H Fujiyoshi Yoshinori Y Honigmann Alf A Uchida Seiichi S Ishihama Yasushi Y Toyoshima Fumiko F
Science advances 20211117 47
Epithelial barriers that prevent dehydration and pathogen invasion are established by tight junctions (TJs), and their disruption leads to various inflammatory diseases and tissue destruction. However, a therapeutic strategy to overcome TJ disruption in diseases has not been established because of the lack of clinically applicable TJ-inducing molecules. Here, we found TJ-inducing peptides (JIPs) in mice and humans that corresponded to 35 to 42 residue peptides of the C terminus of alpha 1-antitr ...[more]