Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers.

ABSTRACT:

Objectives

To estimate lifetime risk of developing rheumatoid arthritis-associated interstitial lung disease (RA-ILD) with respect to the strongest known risk factor for pulmonary fibrosis, a MUC5B promoter variant.

Methods

FinnGen is a collection of epidemiological cohorts and hospital biobank samples, integrating genetic data with up to 50 years of follow-up within nationwide registries in Finland. Patients with RA and ILD were identified from the Finnish national hospital discharge, medication reimbursement and cause-of-death registries. We estimated lifetime risks of ILD by age 80 with respect to the common variant rs35705950, a MUC5B promoter variant.

Results

Out of 293 972 individuals, 1965 (0.7%) developed ILD by age 80. Among all individuals in t

SUBMITTER: Palomaki A 

PROVIDER: S-EPMC8600604 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature