Risk factors associated with prolonged viral clearance in patients with a refractory course of COVID-19: a retrospective study.

ABSTRACT:

Background

This study aimed to characterize a cohort of patients with a refractory course of COVID-19, and to investigate factors associated with the duration of viral clearance (DoVC).

Materials & methods

A total of 65 patients with refractory COVID-19 were retrospectively enrolled from Huoshenshan Hospital. Univariate analysis and multivariate analysis were performed to examine the potential association between clinicopathologic characteristics and the DoVC.

Results

The median DoVC in the overall study cohort was 48 days (ranged from 21 to 104 days). Multivariate analysis indicated that fever at illness onset (Hazard ratio (HR) = 4.897, 95% CI [1.809-13.260], p = 0.002), serum level of aspartate aminotransferase (AST) > 21.8 IU/L (HR = 3.010, 95% CI [1.195-7.

SUBMITTER: Zhuang W 

PROVIDER: S-EPMC8621710 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature