Effects of exercise on the expression of long non-coding RNAs in the bone of mice with osteoporosis.

ABSTRACT: Physical activity or exercise are known to promote bone formation and decrease bone resorption to maintain skeletal and bone health both in animal models and in humans with osteoporosis. Previous studies have indicated that long non-coding RNAs (lncRNAs) are able to regulate bone metabolism. Therefore, the present study aimed to evaluate whether lncRNAs responded to exercise by regulating the balance of bone metabolism in order to prevent osteoporosis. To meet this end, ovariectomized mice were used in the present study to establish an osteoporosis model. The exercise treatment groups were subjected to 9 weeks of treadmill running exercise in 4 weeks of the operation was performed Femurs were collected to measure bone mineral density, bone mass, bone formation and resorption. The expressio

SUBMITTER: Guo J 

PROVIDER: S-EPMC8649853 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature