Single-Cell Chemistry of Photoactivatable Platinum Anticancer Complexes.

ABSTRACT: The Pt(IV) prodrug trans, trans, trans-[Pt(pyridine)₂(N₃)₂(OH)₂] (Pt1) and its coumarin derivative trans, trans, trans-[Pt(pyridine)₂(N₃)₂(OH)(coumarin-3-carboxylate)] (Pt2) are promising agents for photoactivated chemotherapy. These complexes are inert in the dark but release Pt(II) species and radicals upon visible light irradiation, resulting in photocytotoxicity toward cancer cells. Here, we have used synchrotron techniques to investigate the in-cell behavior of these prodrugs and visualize, for the first time, changes in cellular morphology and Pt localization upon treatment with and without light irradiation. We show that photoactivation of Pt2 induces remarkable cellular d

SUBMITTER: Bolitho EM 

PROVIDER: S-EPMC8662725 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature