Individual-level Association of Influenza Infection With Subsequent Pneumonia: A Case-control and Prospective Cohort Study.

ABSTRACT:

Background

Pneumonia is a leading cause of mortality worldwide. Influenza may result in primary pneumonia or be associated with secondary bacterial pneumonia. While the association with secondary pneumonia has been established ecologically, individual-level evidence remains sparse and the risk period for pneumonia following influenza poorly defined.

Methods

We conducted a matched case-control study and a prospective cohort study among Nicaraguan children aged 0-14 years from 2011 through 2018. Physicians diagnosed pneumonia cases based on Integrated Management for Childhood Illness guidelines. Cases were matched with up to 4 controls on age (months) and study week. We fit conditional logistic regression models to assess the association between influenza subtype and subsequen

SUBMITTER: Kubale J 

PROVIDER: S-EPMC8662761 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature