Ontology highlight
ABSTRACT:
SUBMITTER: McReynolds MR
PROVIDER: S-EPMC8678178 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
McReynolds Melanie R MR Chellappa Karthikeyani K Chiles Eric E Jankowski Connor C Shen Yihui Y Chen Li L Descamps Hélène C HC Mukherjee Sarmistha S Bhat Yashaswini R YR Lingala Siddharth R SR Chu Qingwei Q Botolin Paul P Hayat Faisal F Doke Tomohito T Susztak Katalin K Thaiss Christoph A CA Lu Wenyun W Migaud Marie E ME Su Xiaoyang X Rabinowitz Joshua D JD Baur Joseph A JA
Cell systems 20210923 12
NAD<sup>+</sup> is an essential coenzyme for all living cells. NAD<sup>+</sup> concentrations decline with age, but whether this reflects impaired production or accelerated consumption remains unclear. We employed isotope tracing and mass spectrometry to probe age-related changes in NAD<sup>+</sup> metabolism across tissues. In aged mice, we observed modest tissue NAD<sup>+</sup> depletion (median decrease ∼30%). Circulating NAD<sup>+</sup> precursors were not significantly changed, and isotope ...[more]