Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity.

ABSTRACT:

Background

Recent evidence has shown dopamine as a major regulator of inflammation. Accordingly, dopaminergic regulation of immune cells plays an important role in the physiopathology of inflammatory disorders. Multiple sclerosis (MS) is an inflammatory disease involving a CD4⁺ T-cell-driven autoimmune response to central nervous system (CNS) derived antigens. Evidence from animal models has suggested that B cells play a fundamental role as antigen-presenting cells (APC) re-stimulating CD4⁺ T cells in the CNS as well as regulating T-cell response by mean of inflammatory or anti-inflammatory cytokines. Here, we addressed the role of the dopamine receptor D3 (DRD3), which displays the highest affinity for dopamine, in B cells in animal models of MS.

Methods</

SUBMITTER: Prado C 

PROVIDER: S-EPMC8680379 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature