A Multi-center Genome-wide Association Study of Cervical Dystonia.

ABSTRACT:

Background

Several monogenic causes for isolated dystonia have been identified, but they collectively account for only a small proportion of cases. Two genome-wide association studies have reported a few potential dystonia risk loci; but conclusions have been limited by small sample sizes, partial coverage of genetic variants, or poor reproducibility.

Objective

To identify robust genetic variants and loci in a large multicenter cervical dystonia cohort using a genome-wide approach.

Methods

We performed a genome-wide association study using cervical dystonia samples from the Dystonia Coalition. Logistic and linear regressions, including age, sex, and population structure as covariates, were employed to assess variant- and gene-based genetic associations with disease st

SUBMITTER: Sun YV 

PROVIDER: S-EPMC8688173 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature