Polygenic Risk Scores in a Prospective Parkinson's Disease Cohort.
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ABSTRACT: Background
Ethnic-specific genetic risk assessment framework for Parkinson's disease (PD) is lacking for the Asian population.Objective
We investigated the association of a polygenic risk score (PRS) with PD incidence in a population-based Asian prospective cohort.Methods
Genetic, dietary, and lifestyle information were prospectively collected from 25,646 participants within the Singapore Chinese Health Study cohort. PRS was constructed with Asian-specific and top genome-wide association study variants. The association between PRS and PD incidence was evaluated with multivariable Cox proportional hazard models, Kaplan-Meier survival analysis, and concordance statistics.Results
A total of 333 incident cases were identified after a follow-up period of more than 20 years. Participants with PRS in the top tertile (hazard ratio [HR], 1.81; 95% confidence interval [CI], 1.37-2.39) and middle tertile (HR, 1.35; 95% CI, 1.00-1.83) are at higher risk of developing PD after adjusting for dietary and lifestyle risk factors, with a shorter time to PD event in a Kaplan-Meier survival analysis (P < 0.001).Conclusion
We identified a PRS that was significantly associated with PD incidence in a prospective Chinese cohort after adjusting for dietary and lifestyle factors. © 2021 International Parkinson and Movement Disorder Society.
SUBMITTER: Sia MW
PROVIDER: S-EPMC8688232 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Polygenic Risk Scores in a Prospective Parkinson's Disease Cohort.
Sia Ming-Wei MW Foo Jia-Nee JN Saffari Seyed-Ehsan SE Wong Aidan Sheng-Yong AS Khor Chiea-Chuen CC Yuan Jian-Min JM Tan Eng-King EK Koh Woon-Puay WP Tan Louis Chew-Seng LC
Movement disorders : official journal of the Movement Disorder Society 20210817 12
<h4>Background</h4>Ethnic-specific genetic risk assessment framework for Parkinson's disease (PD) is lacking for the Asian population.<h4>Objective</h4>We investigated the association of a polygenic risk score (PRS) with PD incidence in a population-based Asian prospective cohort.<h4>Methods</h4>Genetic, dietary, and lifestyle information were prospectively collected from 25,646 participants within the Singapore Chinese Health Study cohort. PRS was constructed with Asian-specific and top genome- ...[more]
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