Polygenic Risk Scores in a Prospective Parkinson's Disease Cohort.

ABSTRACT:

Background

Ethnic-specific genetic risk assessment framework for Parkinson's disease (PD) is lacking for the Asian population.

Objective

We investigated the association of a polygenic risk score (PRS) with PD incidence in a population-based Asian prospective cohort.

Methods

Genetic, dietary, and lifestyle information were prospectively collected from 25,646 participants within the Singapore Chinese Health Study cohort. PRS was constructed with Asian-specific and top genome-wide association study variants. The association between PRS and PD incidence was evaluated with multivariable Cox proportional hazard models, Kaplan-Meier survival analysis, and concordance statistics.

Results

A total of 333 incident cases were identified after a follow-up period of more tha

SUBMITTER: Sia MW 

PROVIDER: S-EPMC8688232 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature