Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder.

ABSTRACT:

Background

Alcohol use disorder (AUD) and schizophrenia (SCZ) frequently co-occur, and large-scale genome-wide association studies (GWAS) have identified significant genetic correlations between these disorders.

Methods

We used the largest published GWAS for AUD (total cases = 77 822) and SCZ (total cases = 46 827) to identify genetic variants that influence both disorders (with either the same or opposite direction of effect) and those that are disorder specific.

Results

We identified 55 independent genome-wide significant single nucleotide polymorphisms with the same direction of effect on AUD and SCZ, 8 with robust effects in opposite directions, and 98 with disorder-specific effects. We also found evidence for 12 genes whose pleiotropic associations with AUD and S

SUBMITTER: Johnson EC 

PROVIDER: S-EPMC8738774 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature