Dataset Information

Preoperative Maximum Standardized Uptake Value Associated With Recurrence Risk in Early Lung Cancer.

ABSTRACT:

Background

This study aimed to investigate the maximum standardized uptake value (SUV_max) as a predictor of recurrence and timing of recurrence after resection of early-stage non-small cell lung cancer.

Methods

The study retrospectively reviewed patients from a single institution who underwent lobectomy for stage I to IIa non-small cell lung cancer from 2013 to 2018. Exclusion criteria included preoperative therapy and neuroendocrine histologic type. The study investigators collected recurrence and follow-up data, as well as preoperative SUV_max. A receiver operating characteristic curve was used to identify the optimal SUV_max for predicting recurrence. Kaplan-Meier curves and Cox regression analyses were used to identify predictors of freedom from recurrence (FFR).

Results

The study included 238 patients, 30 (12.6%) of whom had disease recurrence. The receiver operating characteristic curve had an area under the curve of 0.671 and identified 4.93 as the optimal SUV_max cutoff. Patients were stratified into groups on the basis of this value; each group included 119 patients. High SUV_max was associated with larger tumor size, poor differentiation, lymphovascular invasion, and shorter FFR. The proportion of patients without recurrence at 5 years in the low- and high-SUV_max groups were 92.4% and 73.4%, respectively (P < .001). On univariate analysis, poor differentiation (hazard ratio [HR],2.35; 95% confidence interval [CI], 1.04 to 5.31; P = .04), lymphovascular invasion (HR, 3.19; 95% CI, 1.37 to 7.44; P = .007), visceral pleural invasion (HR, 2.33; 95% CI, 1.05 to 5.20; P = .04), and SUV_max 4.93 or greater (HR, 4.51; 95% CI, 1.84 to 11.03; P = .001) predicted FFR. On multivariable analysis, only SUV_max 4.93 or greater remained significant (HR, 5.36; 95% CI, 1.50 to 19.17; P = .01).

Conclusions

SUV_max is independently associated with a risk of recurrence after resection of early-stage lung cancer. SUV_max may be a valuable tool for stratifying patients with early-stage lung cancer for adjuvant therapy and surveillance frequency.

SUBMITTER: Blumenthaler AN

PROVIDER: S-EPMC8742841 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Preoperative Maximum Standardized Uptake Value Associated With Recurrence Risk in Early Lung Cancer.

Blumenthaler Alisa N AN Hofstetter Wayne L WL Mehran Reza J RJ Rajaram Ravi R Rice David C DC Roth Jack A JA Sepesi Boris B Swisher Stephen G SG Vaporciyan Ara A AA Walsh Garrett L GL Strange Chad D CD Antonoff Mara B MB

The Annals of thoracic surgery 20210709 6

<h4>Background</h4>This study aimed to investigate the maximum standardized uptake value (SUV<sub>max</sub>) as a predictor of recurrence and timing of recurrence after resection of early-stage non-small cell lung cancer.<h4>Methods</h4>The study retrospectively reviewed patients from a single institution who underwent lobectomy for stage I to IIa non-small cell lung cancer from 2013 to 2018. Exclusion criteria included preoperative therapy and neuroendocrine histologic type. The study investiga ...[more]

PMID: 34252403

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Project description:BackgroundThe pro-tumoral action of the cluster of differentiation 147 (CD147), which is associated with the chemotherapy resistance of lung adenocarcinoma, is partly due to accelerated tumor cell glycolysis. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) metabolic parameters included maximal standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), which are non-invasive markers of the glucose metabolism of tumor cells in vivo. This study aimed to clarify the correlation between PET metabolic parameters and CD147 expression, and to evaluate the prognostic value of CD147 expression in resectable lung adenocarcinoma patients.MethodsA total of 89 lung adenocarcinoma chemotherapy-naive patients who underwent 18F-fluorodeoxyglucose positron emission tomography and computerized tomography scan before pulmonary surgery were retrospectively analyzed. The PET metabolic parameters were calculated by 18F-FDG PET imaging, and CD147 expression was analyzed by immunohistochemistry. SUVmax, SUVmean, MTV, and TLG compared for their performance in predicting the expression of CD147 were illustrated with statistical analysis. All patients were then followed-up for survival analysis.ResultsThe SUVmax was significantly correlated with the CD147 expression and was the primary predictor for the CD147 expression of lung adenocarcinoma. A cut-off value of the SUVmax, 9.77 allowed 85.1% sensitivity and 64.3% specificity for predicting the CD147 positive lung adenocarcinoma. CD147 expression was correlated with tumor differentiation and metastasis. Univariate survival analysis showed that CD147 expression was significantly associated with a shorter overall survival (OS) time. Multivariate analysis revealed that CD147 was an independent prognostic factor of lung adenocarcinoma patients.ConclusionThe SUVmax of a primary tumor measured with 18F-FDG PET may be a simple and non-invasive marker for predicting CD147 expression in lung adenocarcinoma. CD147 is an independent prognostic factor related to OS of postoperative lung adenocarcinoma patients.

Dataset Information

Preoperative Maximum Standardized Uptake Value Associated With Recurrence Risk in Early Lung Cancer.

Background

Methods

Results

Conclusions

Publications

Preoperative Maximum Standardized Uptake Value Associated With Recurrence Risk in Early Lung Cancer.

Similar Datasets

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