Dataset Information

Common clinical features of unilateral retinal pigment epithelium dysgenesis and combined hamartoma of the retina and retinal pigment epithelium.

ABSTRACT:

Background

Herein, we report two cases of unilateral retinal pigment epithelium dysgenesis (URPED) in Chinese patients and explore the relationship between URPED and combined hamartoma of the retina and retinal pigment epithelium (CHRRPE).

Case presentation

The lesion margins in the two cases showed pathognomonic clinical features of URPED, namely, a scalloped reticular margin in hyperplastic retinal pigment epithelium and mild fibrosis. The hypoautofluorescence observed by fundus autofluorescence was inverted compared with that observed by fundus fluorescence angiography. A large amount of fibroglial proliferation and disorganization of the retina involving the whole layer, which are also found in peripapillary CHRRPE, were found in the lesions.

Conclusions

URPED appears to share some clinical features with CHRRPE, and the relationship between URPED and CHRRPE needs further study.

SUBMITTER: Zhu Z

PROVIDER: S-EPMC8760665 | biostudies-literature |

REPOSITORIES: biostudies-literature

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