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Neuronal population activity dynamics reveal a low-dimensional signature of operant learning in Aplysia.

ABSTRACT: Learning engages a high-dimensional neuronal population space spanning multiple brain regions. However, it remains unknown whether it is possible to identify a low-dimensional signature associated with operant conditioning, a ubiquitous form of learning in which animals learn from the consequences of behavior. Using single-neuron resolution voltage imaging, here we identify two low-dimensional motor modules in the neuronal population underlying Aplysia feeding. Our findings point to a temporal shift in module recruitment as the primary signature of operant learning. Our findings can help guide characterization of learning signatures in systems in which only a smaller fraction of the relevant neuronal population can be monitored.

SUBMITTER: Costa RM

PROVIDER: S-EPMC8786933 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Neuronal population activity dynamics reveal a low-dimensional signature of operant learning in Aplysia.

Costa Renan M RM Baxter Douglas A DA Byrne John H JH

Communications biology 20220124 1

Learning engages a high-dimensional neuronal population space spanning multiple brain regions. However, it remains unknown whether it is possible to identify a low-dimensional signature associated with operant conditioning, a ubiquitous form of learning in which animals learn from the consequences of behavior. Using single-neuron resolution voltage imaging, here we identify two low-dimensional motor modules in the neuronal population underlying Aplysia feeding. Our findings point to a temporal s ...[more]

PMID: 35075264

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