Altered cerebellar-cortical resting-state functional connectivity in cannabis users.

ABSTRACT:

Background

Cannabis use has been associated with abnormalities in cerebellar mediated motor and non-motor (i.e. cognition and personality) phenomena. Since the cerebellum is a region with high cannabinoid type 1 receptor density, these impairments may reflect alterations of signaling between the cerebellum and other brain regions.

Aims

We hypothesized that cerebellar-cortical resting-state functional connectivity (rsFC) would be altered in cannabis users, relative to their non-using peers. It was also hypothesized that differences in rsFC would be associated with cannabis use features, such as age of initiation and lifetime use.

Methods

Cerebellar-cortical and subcortical rsFCs were computed between 28 cerebellar lobules, defined by a spatially unbiased atlas template

SUBMITTER: Schnakenberg Martin AM 

PROVIDER: S-EPMC8813046 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature