Polymorphisms in autophagy genes are genetic susceptibility factors in glioblastoma development.

ABSTRACT:

Background

Glioblastoma is the most aggressive and common malignant primary brain tumor in adults. Many genetic, epigenetic and genomic mutations have been identified in this tumor, but no driving cause has been identified yet for glioblastoma pathogenesis. Autophagy has proved to be deregulated in different diseases such as cancer where it has a dual role, acting as a tumor suppression mechanism during the first steps of tumor development and promoting cancer cells survival in stablished tumors.

Methods

Here, we aimed to assess the potential association between several candidate polymorphisms in autophagy genes (ATG2B rs3759601, ATG16L1 rs2241880, ATG10 rs1864183, ATG5 rs2245214, NOD2 rs2066844 and rs2066845) and glioblastoma susceptibility.

Results

Our results showe

SUBMITTER: Bueno-Martinez E 

PROVIDER: S-EPMC8818195 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature